2009 Generation of a Gastrointestinal
Cancer
Tumor Bank
Project Directors:
Wells Messersmith, MD and Colin Weekes, MD
University of Colorado Cancer Center
The University of Colorado Cancer Center (UCCC) used funds received in 2009 from the Golfers Against Cancer Denver Chapter to develop a gastrointestinal (GI) cancer tumor bank focused on colorectal and pancreas cancer.
Cancer research often uses samples of tumors donated by a patient during surgery. Over the past several years, UCCC has developed banks of these samples, which are linked with detailed information about each tumor in a database. Using the physical samples and data, researchers can investigate ideas such as factors that lead to tumor response to treatment and patient prognosis.
UCCC is integrating the GI tumor bank with other UCCC tumor banks, including breast cancer and melanoma, to allow researchers to identify similarities and differences between tumors that develop in different places in the body, including particular molecular or gene defects that characterize each tumor. Simultaneously, the UCCC GI cancer program has developed a tumor bank to help develop new molecular-targeted cancer drugs.
While new, these resources are already impacting the work of UCCC GI cancer researchers. Dr. Wells Messersmith, a colorectal cancer physician and researcher received a $1.25 million grant from the National Institutes of Health, thanks in part to his ability to use specimens collected in the GI tumor bank. Dr. Messersmith will use the grant to develop new colorectal cancer drugs that target a molecule involved in cell growth and movement.
The GI Tumor Bank will continue to be a resource that facilitates research advances in our understanding of GI cancers and for the development of molecular-targeted therapies for them.
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2009 check presentation by Scott Pearson and Lane Cutter to the
University of Colorado Cancer Center
2009 Funded Projects |
2009 Funded Project Research Update
Gift of Life and Breath Foundation
and Accountability Report
Golfers Against Cancer Research Grant
Through the generous support of the Golfer’s Against Cancer organization the Gift of Life and Breath Foundation has been able to continue and advance research in the early detection of lung cancer. Specifically the grant has allowed us to continue research on a specific biomarker we believe may aid in the early detection of lung cancer. Thymidine Kinase-1 or TK-1 is a molecule that is produced in excess quantity in cancer cells. We are developing a test that hopefully will be able to detect TK-1 in the serum of patients with lung cancer. During the past year the most significant advance noted is the improvement in the assay sensitivity which will help to detect even smaller amounts of TK-1 in patient with lung cancer. A portion of the work attributed to the Golfers Against Cancer grant will be submitted for presentation at the 2011 American Association for Cancer Research Annual meeting. This work would not have been possible without the support of the grant. |
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